Macrophages Restrain Contraction of an In Vitro Wound Healing Model

  title={Macrophages Restrain Contraction of an In Vitro Wound Healing Model},
  author={P. M. Newton and J. A. Watson and R. G. Wolowacz and E. Wood},
  • P. M. Newton, J. A. Watson, +1 author E. Wood
  • Published 2004
  • Medicine, Biology
  • Inflammation
  • Significant numbers of macrophages are present during all stages of dermal wound repair, but the functional significance of these macrophages, especially during the later contraction and remodelling stages of repair, remains unclear. We investigated the effect of macrophages on wound contraction using a novel in vitro model based upon the contracting dermal equivalent (DE). Macrophages were found to reversibly restrain DE contraction, a rapid and sustained effect that was enhanced by… CONTINUE READING
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