Macrophages Reprogrammed In Vitro Towards the M1 Phenotype and Activated with LPS Extend Lifespan of Mice with Ehrlich Ascites Carcinoma

@inproceedings{Kalish2015MacrophagesRI,
  title={Macrophages Reprogrammed In Vitro Towards the M1 Phenotype and Activated with LPS Extend Lifespan of Mice with Ehrlich Ascites Carcinoma},
  author={Sergey V. Kalish and Svetlana V. Lyamina and Elena A. Usanova and Eugenia B. Manukhina and Nikolai P. Larionov and Igor Yu Malyshev},
  booktitle={Medical science monitor basic research},
  year={2015}
}
BACKGROUND The majority of tumors trigger macrophage reprogramming from an anti-tumor M1 phenotype towards a pro-tumor M2 phenotype. The M2 phenotype promotes tumor growth. We hypothesized that increasing the number of M1 macrophages in a tumor would limit carcinogenesis and extend the lifespan of the tumor host. The aim of this study was to verify this hypothesis in Ehrlich ascites carcinoma (EAC). The objectives were to evaluate effects of 1) EAC on a macrophage phenotype and NO-producing… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 63 references

Macrophage activation and polarization.

Frontiers in bioscience : a journal and virtual library • 2008
View 3 Excerpts
Highly Influenced

The two faces of IL-6 on Th1/Th2 differentiation.

Molecular immunology • 2002
View 5 Excerpts
Highly Influenced

The past, present and future of immunotherapy against tumor.

Translational lung cancer research • 2015
View 1 Excerpt

[Effect of Brucea javanica fruit oil emulsion combined cisplatin on the growth inhibition of transplanted tumor in human ovarian cancer SKOV3 nude mice: an experimental study].

Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine • 2015
View 1 Excerpt

Similar Papers

Loading similar papers…