Macrophages: central regulators of iron balance.

@article{Gammella2014MacrophagesCR,
  title={Macrophages: central regulators of iron balance.},
  author={Elena Gammella and Paolo Buratti and Gaetano Cairo and Stefania Recalcati},
  journal={Metallomics : integrated biometal science},
  year={2014},
  volume={6 8},
  pages={
          1336-45
        }
}
Macrophages are important to immune function and also actively participate in iron homeostasis. The involvement of splenic and liver macrophages in the processing of effete erythrocytes and the subsequent return of iron to the circulation is well established, and the molecular details of iron recycling have been characterized recently. Another important aspect regarding iron handling by macrophages is their capacity to act as immune cells, which involves the inflammatory response, as well as… CONTINUE READING

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