Macrophages: a crucial reservoir for human immunodeficiency virus in the body.

@article{Balestra2001MacrophagesAC,
  title={Macrophages: a crucial reservoir for human immunodeficiency virus in the body.},
  author={Emanuela Balestra and Carlo Federico Perno and Stefano Aquaro and Sriwan Panti and Ada Bertoli and Mauro Piacentini and Federica Forbici and Roberta D'arrigo and Raffaele Cali{\`o} and Enrico Garaci},
  journal={Journal of biological regulators and homeostatic agents},
  year={2001},
  volume={15 3},
  pages={
          272-6
        }
}
The replication of Human Immunodeficiency Virus (HIV) in cells of macrophage lineage represents a key pathogenetic event of the neurological damages typically found during the course of this disease. Macrophages are persistently infected cells and thus not susceptible to the cytophatic effect typical of infected activated CD4-lymphocytes. The resistance of macrophages to HIV infection is at least in part mediated by the autocrine production of the nerve growth factor (NGF), a neurokine able to… CONTINUE READING

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