Macrophages: Key regulators of steady-state and demand-adapted hematopoiesis.

@article{McCabe2016MacrophagesKR,
  title={Macrophages: Key regulators of steady-state and demand-adapted hematopoiesis.},
  author={Amanda McCabe and K. MacNamara},
  journal={Experimental hematology},
  year={2016},
  volume={44 4},
  pages={
          213-22
        }
}
Hematopoietic stem cell (HSC) function is required for balanced blood production throughout life; it is thus essential to understand the mechanisms regulating this highly dynamic process. Bone marrow-resident macrophages (Mϕs) have recently emerged as an important component of the HSC niche, where they contribute to regulating HSC and progenitor cell (HSPC) mobilization and function. Here we review the role of macrophages (Mϕs) on immune cell production, HSPC pool size, and mobilization at… Expand
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