Macrophages, oxysterols and atherosclerosis.

  title={Macrophages, oxysterols and atherosclerosis.},
  author={Norihito Shibata and Christopher K. Glass},
  journal={Circulation journal : official journal of the Japanese Circulation Society},
  volume={74 10},
Macrophages play central roles in immunity and homeostasis, and contribute to the pathogenesis of atherosclerosis through their accumulation of cholesterol and the production of inflammatory mediators and cytokines. Recent studies indicate that oxysterols influence diverse aspects of macrophage biology. Rather than simply being intermediates of cholesterol catabolism, oxysterols are also potent bioactive lipids that regulate lipid metabolism, immune function, and cytotoxicity. These functions… CONTINUE READING