Macrophages, Meta-Inflammation, and Immuno-Metabolism

  title={Macrophages, Meta-Inflammation, and Immuno-Metabolism},
  author={Haim Shapiro and Aviv Lutaty and Amiram Ariel},
Current research depicts specific modes of immunity and energy metabolism as being interrelated at the molecular, cellular, organ and organism level. Hence, whereas M2 (alternatively-activated) macrophages dominate insulin-sensitive adipose tissue in the lean, M1-skewed (classically-activated) macrophages accumulate in parallel to adiposity in the obese, and promote inflammation and insulin resistance, that is, meta-inflammation. The latest frontier of immuno-metabolism explores the… CONTINUE READING

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