Macrophage-tropic HIV and SIV envelope proteins induce a signal through the CCR5 chemokine receptor

@article{Weissman1997MacrophagetropicHA,
  title={Macrophage-tropic HIV and SIV envelope proteins induce a signal through the CCR5 chemokine receptor},
  author={Drew Weissman and Ronald L Rabin and James Arthos and Andrea Rubbert and Mark Dybul and Ruth Swofford and S. K. Venkatesan and Joshua M Farber and Anthony S. Fauci},
  journal={Nature},
  year={1997},
  volume={389},
  pages={981-985}
}
Human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) enter target cells by forming a complex between the viral envelope protein and two cell-surface membrane receptors: CD4 and a 7-span transmembrane chemokine receptor (reviewed in refs 1,2,3). Isolates of HIV that differ in cellular tropism use different subsets of chemokine receptors as entry cofactors: macrophage-tropic HIVs primarily use CCR5, whereas T-cell-tropic and dual-tropic isolates use CXCR4 (refs 1,2,3… CONTINUE READING