Macrophage synthesis of nitrite, nitrate, and N-nitrosamines: precursors and role of the respiratory burst.

@article{Iyengar1987MacrophageSO,
  title={Macrophage synthesis of nitrite, nitrate, and N-nitrosamines: precursors and role of the respiratory burst.},
  author={Ravi Iyengar and Dennis J. Stuehr and Michael A Marletta},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1987},
  volume={84 18},
  pages={6369-73}
}
The macrophage cell line RAW 264.7 when activated with Escherichia coli lipopolysaccharide and interferon-gamma synthesized nitrite (NO3-) and nitrate (NO3-). Medium change after the activation showed that L-arginine was the only amino acid essential for this synthesis. D-Arginine would not substitute for L-arginine. Other analogues that could replace L-arginine were L-homoarginine, L-arginine methyl ester, L-arginamide, and the peptide L-arginyl-L-aspartate. L-Argininic acid, L-agmatine, L… CONTINUE READING

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