Macrophage stimulation activity of antimicrobial N,N-dimethylaminoethyl paramylon.

  title={Macrophage stimulation activity of antimicrobial N,N-dimethylaminoethyl paramylon.},
  author={Hideki Sakagami and Kunimi Kikuchi and Makoto Takeda and Takashi Sato and Shinichi Ichikawa and Masato Fujimaki and Chie Wada and Nobuhiko Komatsu},
  journal={In vivo},
  volume={5 2},
Pretreatment with N,N-dimethylaminoethyl (DMAE) paramylon significantly protected mice from infection by various microorganisms. When mouse peritoneal macrophages were cultured with DMAE-paramylon, they showed morphological change (spreading) and elevated NBT-reducing activity. Macrophages prepared from DMAE-paramylon-treated mice had higher NBT-reducing activity than those from control mice. On the other hand, carboxymethyl paramylon and paramylon sulfate, which did not induce appreciable… CONTINUE READING