Macrophage-specific metalloelastase (MMP-12) immunoexpression in the osteochondral unit in osteoarthritis correlates with BMI and disease severity.

@article{Kaspiris2015MacrophagespecificM,
  title={Macrophage-specific metalloelastase (MMP-12) immunoexpression in the osteochondral unit in osteoarthritis correlates with BMI and disease severity.},
  author={Angelos Kaspiris and Lubna Khaldi and Efstathios Chronopoulos and Elias S Vasiliadis and Theodoros B. Grivas and Ioannis Kouvaras and Spyridon Dagkas and Evangelia P Papadimitriou},
  journal={Pathophysiology : the official journal of the International Society for Pathophysiology},
  year={2015},
  volume={22 3},
  pages={143-51}
}
BACKGROUND Metalloproteinase 12 (MMP-12) is induced in chondrocytes during fetal development and malignant transformation. OBJECTIVES The aim of our study is to examine the expression of MMP-12 in the cartilage and the subchondral bone of patients with osteoarthritis (OA) and to correlate its expression with disease severity and anthropometric characteristics. METHODS Overall, 60 sections from 20 patients with idiopathic OA, were examined for the immunolocalization of MMP-12. As controls… CONTINUE READING