Macrophage-specific TLR2 signaling mediates pathogen-induced TNF-dependent inflammatory oral bone loss.

@article{Papadopoulos2013MacrophagespecificTS,
  title={Macrophage-specific TLR2 signaling mediates pathogen-induced TNF-dependent inflammatory oral bone loss.},
  author={George K. Papadopoulos and Ellen O. Weinberg and Paola Massari and Frank C. Gibson and Lee M. Wetzler and Elise Feng-I Morgan and Caroline Attardo Genco},
  journal={Journal of immunology},
  year={2013},
  volume={190 3},
  pages={1148-57}
}
Porphyromonas gingivalis is a primary etiological agent of chronic periodontal disease, an infection-driven chronic inflammatory disease that leads to the resorption of tooth-supporting alveolar bone. We previously reported that TLR2 is required for P. gingivalis-induced alveolar bone loss in vivo, and our in vitro work implicated TNF as a key downstream mediator. In this study, we show that TNF-deficient (Tnf(-/-)) mice are resistant to alveolar bone loss following oral infection with P… CONTINUE READING
34 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 34 extracted citations

Similar Papers

Loading similar papers…