Macrophage scavenger receptor mediates the endocytic uptake and degradation of advanced glycation end products of the Maillard reaction.

@article{Araki1995MacrophageSR,
  title={Macrophage scavenger receptor mediates the endocytic uptake and degradation of advanced glycation end products of the Maillard reaction.},
  author={Naoko Araki and Tomohito Higashi and Taisuke Mori and Rina Shibayama and Yoshiki Kawabe and Tatsuhiko Kodama and Kiyoshi Takahashi and Masayoshi Shichiri and Seikoh Horiuchi},
  journal={European journal of biochemistry},
  year={1995},
  volume={230 2},
  pages={408-15}
}
Modification of proteins by long-term incubation with glucose leads to the formation of advanced glycation end products (AGE). Recent immunological demonstration of the presence of AGE proteins in several human tissues suggests that they may be involved in aging, diabetic complications and atherosclerosis. AGE proteins are taken up by macrophages via the AGE receptor, which is similar to the macrophage scavenger receptor (MSR). In the present study, we examined whether MSR could mediate the… CONTINUE READING
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