Macrophage responses to hypoxia: implications for tumor progression and anti-cancer therapies.

@article{Lewis2005MacrophageRT,
  title={Macrophage responses to hypoxia: implications for tumor progression and anti-cancer therapies.},
  author={Claire E. Lewis and Craig Murdoch},
  journal={The American journal of pathology},
  year={2005},
  volume={167 3},
  pages={627-35}
}
The presence of multiple areas of hypoxia (low oxygen tension) is a hallmark feature of human and experimental tumors. Monocytes are continually recruited into tumors, differentiate into tumor-associated macrophages (TAMs), and then accumulate in these hypoxic areas. A number of recent studies have shown that macrophages respond to the levels of hypoxia found in tumors by up-regulating such transcription factors as hypoxia-inducible factors 1 and 2, which in turn activate a broad array of… CONTINUE READING
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