Macrophage recognition and phagocytosis of apoptotic fibroblasts is critically dependent on fibroblast-derived thrombospondin 1 and CD36.

@article{Moodley2003MacrophageRA,
  title={Macrophage recognition and phagocytosis of apoptotic fibroblasts is critically dependent on fibroblast-derived thrombospondin 1 and CD36.},
  author={Yuben Moodley and Paul Rigby and Chris Bundell and Stuart Bunt and Hideyuki Hayashi and Neil L. A. Misso and Robin J McAnulty and Geoffrey John Laurent and Amelia K Scaffidi and Phillip J. Thompson and Darryl A Knight},
  journal={The American journal of pathology},
  year={2003},
  volume={162 3},
  pages={771-9}
}
The induction of fibroblast apoptosis and their clearance by phagocytes is essential for normal wound healing and prevention of scarring. However, little is known about the clearance of apoptotic fibroblasts and whether apoptotic cells are active participants in the recruitment and activation of phagocytes. In this study, we provide the first evidence that apoptotic fibroblasts actively release increased amounts of thrombospondin (TSP1) to actively recruit macrophages. Expression of TSP1 and… CONTINUE READING

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