Macrophage protein kinase C: its role in modulating membrane microviscosity and superoxide in leishmanial infection.

@article{Chakraborty2000MacrophagePK,
  title={Macrophage protein kinase C: its role in modulating membrane microviscosity and superoxide in leishmanial infection.},
  author={Prarthana Chakraborty and Debjani Das Ghosh and Mukul Kumar Basu},
  journal={Journal of biochemistry},
  year={2000},
  volume={127 2},
  pages={185-90}
}
Pretreatment of macrophages with, an agonist of PKC, showed diverse effects on degradation and survival of two virulent strains of Leishmania donovani promastigotes. Treatment of macrophages with PMA for 45 min at 37 degrees C generated significant amounts of superoxide anions and reduced the parasite burden of macrophages by up to 48 and 43% when AG83 and GE-1 strains were used for infection. Staurosporine, an inhibitor of PKC, inhibited PMA-dependent killing of the parasites, while tyrphostin… CONTINUE READING