Macrophage polarization in tumour progression.

  title={Macrophage polarization in tumour progression.},
  author={Antonio Sica and Paola Larghi and Alessandra Mancino and Luca Agostino Rubino and Chiara Porta and Maria Grazia Totaro and Monica Rimoldi and Subhra Kumar Biswas and Paola Allavena and Alberto Mantovani},
  journal={Seminars in cancer biology},
  volume={18 5},
Macrophages are a fundamental part of the innate defense mechanisms, which can promote specific immunity by inducing T cell recruitment and activation. Despite this, their presence within the tumour microenvironment has been associated with enhanced tumour progression and shown to promote cancer cell growth and spread, angiogenesis and immunosuppression. This paradoxical role of macrophages in cancer finds an explanation in their functional plasticity, that may result in the polarized… CONTINUE READING
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