Macrophage migration inhibitory factor promotes cyst growth in polycystic kidney disease.

@article{Chen2015MacrophageMI,
  title={Macrophage migration inhibitory factor promotes cyst growth in polycystic kidney disease.},
  author={Li Chen and Xia Zhou and Lucy X. Fan and Ying Bang Yao and Katherine I Swenson-Fields and Mihaela G Gadjeva and Darren P Wallace and Dorien J. M. Peters and Alan Yu and J. J. Grantham and Xiaogang Li},
  journal={The Journal of clinical investigation},
  year={2015},
  volume={125 6},
  pages={
          2399-412
        }
}
Autosomal dominant polycystic kidney disease (ADPKD) is characterized by renal cyst formation, inflammation, and fibrosis. Macrophages infiltrate cystic kidneys, but the role of these and other inflammatory factors in disease progression are poorly understood. Here, we identified macrophage migration inhibitory factor (MIF) as an important regulator of cyst growth in ADPKD. MIF was upregulated in cyst-lining epithelial cells in polycystin-1-deficient murine kidneys and accumulated in cyst fluid… CONTINUE READING
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