Macrophage migration inhibitory factor promotes tumor invasion and metastasis via the Rho-dependent pathway.

@article{Sun2005MacrophageMI,
  title={Macrophage migration inhibitory factor promotes tumor invasion and metastasis via the Rho-dependent pathway.},
  author={Bailong Sun and Jun Nishihira and Takashi Yoshiki and Masao Kondo and Yuji Sato and Fumiaki Sasaki and Satoru Todo},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2005},
  volume={11 3},
  pages={1050-8}
}
PURPOSE Macrophage migration inhibitory factor (MIF) plays an important role not only in the immune system but also in tumorigenesis. In this study, we investigated the potential role of MIF in association with tumor invasion and metastasis. METHODS To assess the function of MIF, we knocked down the MIF mRNA using small interfering RNA (siRNA). Twenty-one base siRNA specific for the mRNA sequence of mouse MIF was introduced to a murine colon cancer cell line, colon 26. Tumor cell invasion was… CONTINUE READING

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