Macrophage migration inhibitory factor potentiates autoimmune-mediated neuroinflammation.

  title={Macrophage migration inhibitory factor potentiates autoimmune-mediated neuroinflammation.},
  author={Gina Mavrikis Cox and Aaron P. Kithcart and D. Pitt and Zhen Guan and Jessica P Alexander and Jessica L. Williams and Todd M. Shawler and Nilesh M. Dagia and Phillip G. Popovich and Abhay R Satoskar and Caroline C. Whitacre},
  journal={Journal of immunology},
  volume={191 3},
Macrophage migration inhibitory factor (MIF) is a multipotent cytokine that is associated with clinical worsening and relapses in multiple sclerosis (MS) patients. The mechanism through which MIF promotes MS progression remains undefined. In this study, we identify a critical role for MIF in regulating CNS effector mechanisms necessary for the development of inflammatory pathology in a mouse model of MS, experimental autoimmune encephalomyelitis (EAE). Despite the ability to generate pathogenic… CONTINUE READING
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