Macrophage migration inhibitory factor mediates the antidepressant actions of voluntary exercise.

  title={Macrophage migration inhibitory factor mediates the antidepressant actions of voluntary exercise.},
  author={Hyo Youl Moon and Se Hyun Kim and Yong Yang and Parkyong Song and Hyun Sook Yu and Hong Geun Park and Onyou Hwang and Whaseon Lee-Kwon and Jeong Kon Seo and Daehee Hwang and Jang Hyun Choi and Richard Bucala and Sung Ho Ryu and Yong Sik Kim and Pann Ghill Suh},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={109 32},
Voluntary exercise is known to have an antidepressant effect. However, the underlying mechanism for this antidepressant action of exercise remains unclear, and little progress has been made in identifying genes that are directly involved. We have identified macrophage migration inhibitory factor (MIF) by analyzing existing mRNA microarray data and confirmed the augmented expression of selected genes under two experimental conditions: voluntary exercise and electroconvulsive seizure. A… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 8 times over the past 90 days. VIEW TWEETS
25 Citations
47 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 25 extracted citations


Publications referenced by this paper.
Showing 1-10 of 47 references

Antidepressant actions of the exercise-regulated gene VGF

  • JG Hunsberger
  • Nat Med
  • 2007

Similar Papers

Loading similar papers…