Macrophage migration inhibitory factor is up-regulated in human first-trimester placenta stimulated by soluble antigen of Toxoplasma gondii, resulting in increased monocyte adhesion on villous explants.

@article{Ferro2008MacrophageMI,
  title={Macrophage migration inhibitory factor is up-regulated in human first-trimester placenta stimulated by soluble antigen of Toxoplasma gondii, resulting in increased monocyte adhesion on villous explants.},
  author={Elo{\'i}sa Am{\'a}lia Vieira Ferro and Jos{\'e} Roberto Mineo and Francesca Ietta and Nicoletta Bechi and Roberta Romagnoli and Deise Aparecida de Oliveira Silva and Giuseppina Sorda and Estela Bevilacqua and Luana Paulesu},
  journal={The American journal of pathology},
  year={2008},
  volume={172 1},
  pages={50-8}
}
Considering the potential role of macrophage migration inhibitory factor (MIF) in the inflammation process in placenta when infected by pathogens, we investigated the production of this cytokine in chorionic villous explants obtained from human first-trimester placentas stimulated with soluble antigen from Toxoplasma gondii (STAg). Parallel cultures were performed with villous explants stimulated with STAg, interferon-gamma (IFN-gamma), or STAg plus IFN-gamma. To assess the role of placental… CONTINUE READING
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