Macrophage migration inhibitory factor involvement in breast cancer (Review)

  title={Macrophage migration inhibitory factor involvement in breast cancer (Review)},
  author={Vincent Richard and Nad{\`e}ge Kindt and Sven Saussez},
  booktitle={International journal of oncology},
Macrophage migration inhibitory factor (MIF) is a pleiotropic inflammatory cytokine involved in many cellular processes and in particular carcinogenesis. Here, we review the experimental and clinical published data on MIF and its pathways in breast cancer. Experimental data show that MIF is overexpressed in breast cancer cells (BCC) due, at least partly, to its stabilization by HSP90 and upregulation by HIF-1α. MIF interacts with its main receptor CD74 and its co-receptor CXCR-4, both… CONTINUE READING
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