Macrophage migration inhibitory factor induces cardiomyocyte apoptosis.

  title={Macrophage migration inhibitory factor induces cardiomyocyte apoptosis.},
  author={Preeta Dhanantwari and Sumekala Nadaraj and Agnes Kenessey and Devyani Chowdhury and Yousef Al-Abed and Edmund J Miller and Kaie Ojamaa},
  journal={Biochemical and biophysical research communications},
  volume={371 2},
Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine that causes cardiac contractile dysfunction, whereas inactivation of MIF improves cardiac function in experimental animal models of sepsis. We used cultured cardiomyocytes to determine whether MIF-induced contractile dysfunction was mediated in part by myocyte apoptosis and to identify MIF-activated intracellular signaling pathways in this process. MIF treatment significantly increased myocyte apoptosis in a dose… CONTINUE READING


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