Macrophage migration inhibitory factor enzymatic activity, lung inflammation, and cystic fibrosis.

@article{Adamali2012MacrophageMI,
  title={Macrophage migration inhibitory factor enzymatic activity, lung inflammation, and cystic fibrosis.},
  author={Huzaifa I. Adamali and Michelle E. Armstrong and Anne Marie Mclaughlin and Gordon Cooke and Edward F McKone and Christine M. Costello and Charles G. Gallagher and Lin Leng and John A. Baugh and Guenter Fingerle-Rowson and Richard Bucala and Paul McLoughlin and Seamas Donnelly},
  journal={American journal of respiratory and critical care medicine},
  year={2012},
  volume={186 2},
  pages={162-9}
}
RATIONALE Macrophage migration inhibitory factor (MIF) is a proinflammatory mediator with unique tautomerase enzymatic activity; the precise function has not been clearly defined. We previously demonstrated that individual patients with cystic fibrosis (CF) who are genetically predisposed to be high MIF producers develop accelerated end-organ injury… CONTINUE READING