Macrophage mediated protein hydroperoxide formation and lipid oxidation in low density lipoprotein are inhibited by the inflammation marker 7,8-dihydroneopterin.

@article{Firth2008MacrophageMP,
  title={Macrophage mediated protein hydroperoxide formation and lipid oxidation in low density lipoprotein are inhibited by the inflammation marker 7,8-dihydroneopterin.},
  author={Carole A Firth and Elizabeth M Crone and Elizabeth A Flavall and Justin Allan Roake and Steven P Gieseg},
  journal={Biochimica et biophysica acta},
  year={2008},
  volume={1783 6},
  pages={1095-101}
}
The formation of oxidised low density lipoprotein (LDL) within the atherosclerotic plaque appears to be a factor in the development of advanced atherosclerotic plaques. LDL oxidation is dependent on the balance of oxidants and antioxidants within the intima. In addition to producing various oxidants, human macrophages release 7,8-dihydroneopterin which in vivo is oxidised to the inflammation marker neopterin. Using macrophage-like THP-1 cells and human monocyte-derived macrophages, we… CONTINUE READING

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