Macrophage-mediated 15-lipoxygenase expression protects against atherosclerosis development.

@article{Shen1996Macrophagemediated1E,
  title={Macrophage-mediated 15-lipoxygenase expression protects against atherosclerosis development.},
  author={Joseph J Shen and Edward E. Herderick and J. Frederic Cornhill and Elemer Zsigmond and Hyun Soo Kim and Hartmut Michael K{\"u}hn and Natalia V. Guevara and Lavena Chan},
  journal={The Journal of clinical investigation},
  year={1996},
  volume={98 10},
  pages={
          2201-8
        }
}
Oxidative modification of LDL increases its atherogenicity, and 15-lipoxygenase (15-LO) has been implicated in the process. To address this issue, we generated transgenic rabbits that expressed 15-LO in a macrophage-specific manner and studied their susceptibility to atherosclerosis development when they were fed a high-fat, high-cholesterol (HFHC) diet (Teklad 0533 rabbit diet 7009 with 10% corn oil and 0.25% cholesterol) for 13.5 wk. Transgenic and nontransgenic rabbits developed similar… CONTINUE READING

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