Macrophage matrix metalloproteinase-9 mediates epithelial-mesenchymal transition in vitro in murine renal tubular cells.

@article{Tan2010MacrophageMM,
  title={Macrophage matrix metalloproteinase-9 mediates epithelial-mesenchymal transition in vitro in murine renal tubular cells.},
  author={Thian Kui Tan and Guoping Zheng and Tzu-Ting Hsu and Ying Wang and Vincent W. S. Lee and Xinrui Tian and Yiping Wang and Qi Cao and Ya na Wang and David C. H. Harris},
  journal={The American journal of pathology},
  year={2010},
  volume={176 3},
  pages={
          1256-70
        }
}
As a rich source of pro-fibrogenic growth factors and matrix metalloproteinases (MMPs), macrophages are well-placed to play an important role in renal fibrosis. However, the exact underlying mechanisms and the extent of macrophage involvement are unclear. Tubular cell epithelial-mesenchymal transition (EMT) is an important contributor to renal fibrosis and MMPs to induction of tubular cell EMT. The aim of this study was to investigate the contribution of macrophages and MMPs to induction of… CONTINUE READING

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