Macrophage lipoprotein lipase promotes foam cell formation and atherosclerosis in low density lipoprotein receptor-deficient mice.

@article{Babaev2000MacrophageLL,
  title={Macrophage lipoprotein lipase promotes foam cell formation and atherosclerosis in low density lipoprotein receptor-deficient mice.},
  author={Vladimir R. Babaev and Meenakshi Bhavesh Patel and Clay F Semenkovich and Sergio Fazio and Macrae F Linton},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 34},
  pages={26293-9}
}
The role of macrophage lipoprotein lipase (LPL) expression in atherosclerotic lesion formation was examined in low density lipoprotein receptor (LDLR(-/-)) mice using dietary conditions designed to induce either fatty streak lesions or complex atherosclerotic lesions. First, LDLR(-/-) mice chimeric for macrophage LPL expression were created by transplantation of lethally irradiated female LDLR(-/-) mice with LPL(-/-) (n = 12) or LPL(+/+) (n = 14) fetal liver cells as a source of hematopoietic… CONTINUE READING

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