Macrophage lectins in host defence.

  title={Macrophage lectins in host defence.},
  author={Sheena A. Linehan and Luisa Martinez-Pomares and Siamon Gordon},
  journal={Microbes and infection},
  volume={2 3},
Macrophage lectins contribute to host defence by a variety of mechanisms. The best characterised, mannose receptor (MR) and complement receptor three (CR3), are both able to mediate phagocytosis of pathogenic microbes and induce intracellular killing mechanisms. The regulation of the effector functions induced via MR is complex, and may involve both host and microbial factors. Therefore, MR is likely to play a dynamic role in the response to infection; it may act as a classical pattern… CONTINUE READING

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