Macrophage labeling by SPIO as an early marker of allograft chronic rejection in a rat model of kidney transplantation.

@article{Beckmann2003MacrophageLB,
  title={Macrophage labeling by SPIO as an early marker of allograft chronic rejection in a rat model of kidney transplantation.},
  author={Nicolau Beckmann and Catherine Cannet and Madeleine Fringeli-Tanner and Diana R Baumann and Charles Pally and Christian Bruns and H G Zerwes and Emile Andriambeloson and Marc Bigaud},
  journal={Magnetic resonance in medicine},
  year={2003},
  volume={49 3},
  pages={459-67}
}
Anatomical and functional information (renography, perfusion) was obtained by MRI in a life-supporting transplantation model, in which Lewis rats received kidneys from Fisher 344 donors. Renography and perfusion analyses were carried out with Gd-DOTA and small particles of iron oxide (SPIO), respectively. Starting 12 weeks posttransplantation, images from grafts of untreated recipients exhibited distinctive signal attenuation in the cortex. Animals treated with cyclosporin (Sandimmune Neoral… CONTINUE READING

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