Macrophage killing of Leishmania parasite in vivo is mediated by nitric oxide from L-arginine.

@article{Liew1990MacrophageKO,
  title={Macrophage killing of Leishmania parasite in vivo is mediated by nitric oxide from L-arginine.},
  author={Foo Yew Eddy Liew and S M Millott and Craig Parkinson and Richard M J Palmer and Salvador Moncada},
  journal={Journal of immunology},
  year={1990},
  volume={144 12},
  pages={4794-7}
}
Peritoneal macrophages from CBA mice incubated with rIFN-gamma are effective in killing the protozoal parasite Leishmania major in vitro. This leishmanicidal activity can be completely inhibited by L-NG-monomethyl arginine (L-NMMA), a specific inhibitor of the L-arginine:nitric oxide (NO) pathway. The culture supernatants of macrophage activated by IFN-gamma contain increased levels of NO2-, the production of which is inhibited by L-NMMA, but not by its D-enantiomer. L. major promastigotes are… CONTINUE READING

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