Macrophage invasion does not contribute to muscle membrane injury during inflammation

  title={Macrophage invasion does not contribute to muscle membrane injury during inflammation},
  author={J. Tidball and E. Berchenko and J. Frenette},
  journal={Journal of Leukocyte Biology},
  • J. Tidball, E. Berchenko, J. Frenette
  • Published 1999
  • Biology, Medicine
  • Journal of Leukocyte Biology
  • Previous observations have shown that neutrophil invasion precedes macrophage invasion during muscle inflammation and that peak muscle injury is observed at the peak of ED1+ macrophage invasion. We tested the hypothesis that neutrophil invasion causes subsequent invasion by ED1+ macrophages and that ED1+ macrophages then contribute significantly to muscle membrane injury during modified muscle use. Rat hindlimbs were unloaded for 10 days followed by reloading by normal ambulation to induce… CONTINUE READING
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