Macrophage inhibitory factor, plasminogen activator inhibitor-1, other acute phase proteins, and inflammatory mediators normalize as a result of weight loss in morbidly obese subjects treated with gastric restrictive surgery.

@article{Dielen2004MacrophageIF,
  title={Macrophage inhibitory factor, plasminogen activator inhibitor-1, other acute phase proteins, and inflammatory mediators normalize as a result of weight loss in morbidly obese subjects treated with gastric restrictive surgery.},
  author={Francois M. H. van Dielen and Wim A. Buurman and M'hamed Hadfoune and Jeroen Oude Nijhuis and Jan Willem W. M. Greve},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2004},
  volume={89 8},
  pages={
          4062-8
        }
}
Obesity is demonstrated to be associated with an enhanced inflammatory state, which is suggested to be a cause for the development of obesity-related morbidity. It was hypothesized that a decrease in body weight in morbid obese subjects would lead to a reduction of the inflammatory state in these subjects. Weight loss was achieved by gastric restrictive surgery in 27 morbidly obese patients. Preoperative as well as 3-, 6-, 12-, and 24-month postoperative plasma concentrations of inflammatory… CONTINUE READING
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