Corpus ID: 27872584

Macrophage inhibitory cytokine-1 induces the invasiveness of gastric cancer cells by up-regulating the urokinase-type plasminogen activator system.

@article{Lee2003MacrophageIC,
  title={Macrophage inhibitory cytokine-1 induces the invasiveness of gastric cancer cells by up-regulating the urokinase-type plasminogen activator system.},
  author={D. Lee and Young Yang and Soonduck Lee and Kun-Yong Kim and T. Koo and S. Shin and K. Song and Y. Lee and Yung-Jin Kim and Jung Joon Lee and I. Choi and Jeong-Hyung Lee},
  journal={Cancer research},
  year={2003},
  volume={63 15},
  pages={
          4648-55
        }
}
In our search for genes associated with gastric cancer progression, we identified macrophage inhibitory cytokine-1 (MIC-1), a member of the transforming growth factor beta superfamily, as an overexpressed gene in gastric tumor tissues. Expression analysis of MIC-1 in gastric tumor tissues revealed a specific expression in gastric cancer cells, and this expression level was well correlated with invasive potential in various human gastric cancer cell lines. Stable transfection of MIC-1 into SNU… Expand
Upregulation and secretion of macrophage inhibitory cytokine-1 (MIC-1) in gastric cancers.
  • K. Baek, S. Yoon, +8 authors Hee-Gu Lee
  • Biology, Medicine
  • Clinica chimica acta; international journal of clinical chemistry
  • 2009
TLDR
Macrophage inhibitory cytokine-1 was obviously overexpressed in gastric cancers and MIC-1 secretion into blood may be useful for the prediction of gastric cancer progression. Expand
IL-1β-stimulated urokinase plasminogen activator expression through NF-κB in gastric cancer after HGF treatment.
TLDR
IL-1β stimulated uPA expression through ERK and NF-κB in Gastric cancer, which may therefore be promising targets for gastric cancer therapy. Expand
Macrophage inhibitory cytokine-1 (MIC-1) and subsequent urokinase-type plasminogen activator mediate cell death responses by ribotoxic anisomycin in HCT-116 colon cancer cells.
TLDR
It is demonstrated that macrophage inhibitory cytokine-1 and its associated signals determined the colon cancer cell response to the chemical ribotoxic stress and subsequent apoptosis while suppressing survival ERK signal in the Colon cancer cells. Expand
The macrophage inhibitory cytokine integrates AKT/PKB and MAP kinase signaling pathways in breast cancer cells.
TLDR
It is shown that AKT/PKB directly regulates the expression of MIC-1 in breast cancer cells and the MIC- 1 expression levels may serve as a surrogate marker for the AKT activation in tumors. Expand
Effect of urokinase-type plasminogen activator system in gastric cancer with peritoneal metastasis.
TLDR
Antibodies for uPA, uPAR and PAI-1 in the uPA system had the ability to inhibit the adhesion, migration and invasion of peritoneal metastasis in the gastric cancer cells. Expand
Overexpression of macrophage inhibitory cytokine-1 induces metastasis of human prostate cancer cells through the FAK–RhoA signaling pathway
TLDR
The findings show that MIC-1 has a role in prostate cancer metastasis, in part, by promoting the motility of these cells by Activation of the FAK–RhoA signaling pathway is involved in MIC- 1-mediated actin reorganization, and thus, leads to an increase in the Motility of prostate cancer cells. Expand
Macrophage inhibitory cytokine-1 activates AKT and ERK-1/2 via the transactivation of ErbB2 in human breast and gastric cancer cells.
TLDR
It is demonstrated that MIC-1 induces the transactivation of ErbB2 in SK-BR-3 breast and SNU-216 gastric cancer cells and performs a crucial function inMIC-1-induced signaling pathways, which may participate in the malignant progression of certain human cancer cells that overexpress Erb B2 through the trans activation of ErBB2 tyrosine kinase. Expand
Macrophage inhibitory cytokine-1 stimulates proliferation of human umbilical vein endothelial cells by up-regulating cyclins D1 and E through the PI3K/Akt-, ERK-, and JNK-dependent AP-1 and E2F activation signaling pathways.
TLDR
The results suggest that MIC-1 secreted from cancer cells stimulates endothelial cell proliferation by enhancing AP-1- and E2F-dependent expression of G(1) cyclins via PI3K/Akt, JNK, and ERK signaling pathways, potentially leading to enhanced tumor angiogenesis. Expand
Enteropathogenic Escherichia coli-induced macrophage inhibitory cytokine 1 mediates cancer cell survival: an in vitro implication of infection-linked tumor dissemination
TLDR
It is concluded that EPEC enhances MIC-1 gene expression in the human intestinal cancer cells, which can be associated with enhanced tumor cell resistance to anchorage-dependent tumor cell death via enhanced TAK1 and RhoA GTPase. Expand
Macrophage inhibitory cytokine-1 regulates melanoma vascular development.
TLDR
In conclusion, MIC-1 is secreted from melanoma cells together with VEGF to promote vascular development mediated by (V600E)B-Raf signaling, acting as a potent angiogenic factor in melanoma angiogenesis. Expand
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References

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Anoxia induces macrophage inhibitory cytokine-1 (MIC-1) in glioblastoma cells independently of p53 and HIF-1
TLDR
Data suggest that MIC-1 is an important downstream mediator of p53 function, while acting itself as an intercessor of cellular stress signaling and exerting anti-tumorigenic activities. Expand
Multifunctional potential of the plasminogen activation system in tumor invasion and metastasis (review).
TLDR
Besides its proteolytic activity, uPA in concert with uPAR exert biological effects characteristic for molecules with signal transducing properties including chemotaxis, migration/invasion, adhesion, and mitogenesis. Expand
Expression of Transforming Growth Factor β Type II Receptor Reduces Tumorigenicity in Human Gastric Cancer Cells
TLDR
A strong association is suggested between the expression of wild-type TGF-β RII and the degree of malignancy in human gastric cancer cells. Expand
Urokinase-type plasminogen activator receptor in gastric cancer: tissue expression and prognostic role
TLDR
The concomitant activation of UPAR, UPA and PAI-1 in GC confirm the important role of the plasminogen activator system in the process of invasion and metastasis and suggest a prognostic role for it. Expand
Syntenin is overexpressed and promotes cell migration in metastatic human breast and gastric cancer cell lines
TLDR
This is the first demonstration that syntenin, a PDZ motif-containing protein, can be overexpressed during the metastatic progression of human breast and gastric cancer cells and that it can function as a metastasis-inducing gene. Expand
The transforming growth factor-ss superfamily cytokine macrophage inhibitory cytokine-1 is present in high concentrations in the serum of pregnant women.
TLDR
It is suggested that the placental trophoblast is a major source of the MIC-1 present in maternal serum and amniotic fluid and that this cytokine may promote fetal survival by suppressing the production of maternally derived proinflammatory cytokines within the uterus. Expand
Placental Transforming Growth Factor-β Is a Downstream Mediator of the Growth Arrest and Apoptotic Response of Tumor Cells to DNA Damage and p53 Overexpression*
TLDR
Results provide the first evidence for a direct functional link between p53 and the TGF- β superfamily and implicate PTGF-β as an important intercellular mediator of p53 function and the cytostatic effects of radiation and chemotherapeutic cancer agents. Expand
MIC-1, a novel macrophage inhibitory cytokine, is a divergent member of the TGF-beta superfamily.
  • M. Bootcov, A. Bauskin, +13 authors S. Breit
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1997
TLDR
Purified recombinant MIC-1 is able to inhibit lipopolysaccharide -induced macrophage TNF-alpha production, suggesting that MIC- 1 acts in macrophages as an autocrine regulatory molecule. Expand
Expression of a novel member of the TGF-β superfamily, growth/differentiation factor-15/macrophage-inhibiting cytokine-1 (GDF-15/MIC-1) in adult rat tissues
TLDR
GDF-15/MIC-1, like many other members of the TGF-β superfamily, is widely distributed in adult tissues, being most strongly expressed in epithelial cells and macrophages. Expand
Expression profile of differentially-regulated genes during progression of androgen-independent growth in human prostate cancer cells.
TLDR
These differentially-regulated genes are correlated with progression of human prostate cancer and may be of therapeutic relevance as well as an aid in understanding the molecular genetic events involved in the development of this disease's hormone-refractory behavior. Expand
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