Macrophage inflammatory protein-2: chromosomal regulation in rat small intestinal epithelial cells.

@article{Ohno1997MacrophageIP,
  title={Macrophage inflammatory protein-2: chromosomal regulation in rat small intestinal epithelial cells.},
  author={Yasuhiro Ohno and Junghee Lee and Robert D Fusunyan and Richard P Macdermott and Ian R Sanderson},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1997},
  volume={94 19},
  pages={10279-84}
}
Nonpathogenic, resident bacteria participate in the pathogenesis of inflammation in the small intestine, but the molecular messages produced by such bacteria are unknown. Inflammatory responses involve the recruitment of specific leukocyte subsets. We, therefore, hypothesized that butyrate, a normal bacterial metabolite, may modulate chemokine secretion by epithelial cells, by amplifying their response to proinflammatory signals. We studied the expression of the chemokine, macrophage… CONTINUE READING