Macrophage infiltration into experimental brain metastases: occurrence through an intact blood-brain barrier.

@article{Schackert1988MacrophageII,
  title={Macrophage infiltration into experimental brain metastases: occurrence through an intact blood-brain barrier.},
  author={Gabriele Schackert and Roger D. Simmons and T. M. Buzbee and David A. Hume and Isaiah Josh Fidler},
  journal={Journal of the National Cancer Institute},
  year={1988},
  volume={80 13},
  pages={1027-34}
}
The purpose of this study was to examine the nature of the blood-brain barrier in experimental brain metastases. Syngeneic fibrosarcoma or melanoma cells were injected into the internal carotid arteries of mice. Several weeks later, once the experimental brain metastases were established, the mice were given injections iv of sodium fluorescein. The capillaries within the metastatic foci were enlarged and irregular, but there was no leakage of sodium fluorescein, showing that the blood-brain… CONTINUE READING