Macrophage heterogeneity in tissues: phenotypic diversity and functions

  title={Macrophage heterogeneity in tissues: phenotypic diversity and functions},
  author={Siamon Gordon and Annette Pl{\"u}ddemann and Fernando Martinez Estrada},
  booktitle={Immunological reviews},
During development and throughout adult life, macrophages derived from hematopoietic progenitors are seeded throughout the body, initially in the absence of inflammatory and infectious stimuli as tissue-resident cells, with enhanced recruitment, activation, and local proliferation following injury and pathologic insults. We have learned a great deal about macrophage properties ex vivo and in cell culture, but their phenotypic heterogeneity within different tissue microenvironments remains… CONTINUE READING