Macrophage glucocorticoid receptors regulate Toll-like receptor 4-mediated inflammatory responses by selective inhibition of p38 MAP kinase.

@article{Bhattacharyya2007MacrophageGR,
  title={Macrophage glucocorticoid receptors regulate Toll-like receptor 4-mediated inflammatory responses by selective inhibition of p38 MAP kinase.},
  author={Sanchari Bhattacharyya and Diane E. Brown and Judson A. Brewer and Sherri K. Vogt and Louis J. Muglia},
  journal={Blood},
  year={2007},
  volume={109 10},
  pages={
          4313-9
        }
}
To explore the role of glucocorticoids in regulation of kinase pathways during innate immune responses, we generated mice with conditional deletion of glucocorticoid receptor (GR) in macrophages (MGRKO). Activation of toll-like receptor 4 (TLR4) by lipopolysaccharide (LPS) caused greater mortality and cytokine production in MGRKO mice than in controls. Ex vivo, treatment with dexamethasone (Dex) markedly inhibited LPS-mediated induction of inflammatory genes in control but not GR-deficient… CONTINUE READING

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