Macrophage factor controlling differentiation of B cells.

  title={Macrophage factor controlling differentiation of B cells.},
  author={Michael K. Hoffmann and Scott Koenig and Robert S. Mittler and Herbert Friedrich Oettgen and Peter Ralph and Chris Galanos and Ulrich Hammerling},
  journal={Journal of immunology},
  volume={122 2},
Peritoneal macrophages of the mouse produce, in response to cell wall components of Gram-negative bacteria (lipopolysaccharide and lipoproteins), a factor that causes antigen-stimulated B cells of differentiate into antibody-producing cells. Unlike lipopolysaccharide, this factor is not mitogenic for B cells. Production of the macrophage factor does not depend on participation of T cells or other accessory cells since it is readily produced by several cloned macrophage cell lines as well as by… CONTINUE READING

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