Macrophage endocytosis of superparamagnetic iron oxide nanoparticles: mechanisms and comparison of ferumoxides and ferumoxtran-10.

@article{Raynal2004MacrophageEO,
  title={Macrophage endocytosis of superparamagnetic iron oxide nanoparticles: mechanisms and comparison of ferumoxides and ferumoxtran-10.},
  author={Isabelle Raynal and Philippe Prigent and Sophie Peyramaure and Abderrahim Najid and C{\'e}cile Rebuzzi and Claire A Corot},
  journal={Investigative radiology},
  year={2004},
  volume={39 1},
  pages={56-63}
}
RATIONALE AND OBJECTIVES Superparamagnetic iron oxides (SPIO) used as magnetic resonance (MR) contrast agents undergo specific uptake by macrophages. The purpose of this study was first to determine the mechanism of macrophage uptake for Ferumoxides by using competition experiments with specific ligands of scavenger receptors SR-A (I/II) and second, to evaluate and compare the internalization of 2 different contrast agents, Ferumoxides (SPIO) and Ferumoxtran-10 (USPIO: ultrasmall… CONTINUE READING
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