Macrophage differentiation-specific expression of NF-IL6, a transcription factor for interleukin-6.

@article{Natsuka1992MacrophageDE,
  title={Macrophage differentiation-specific expression of NF-IL6, a transcription factor for interleukin-6.},
  author={S Natsuka and Shizuo Akira and Yoshihiko Nishio and Shin-ichi Hashimoto and Takahisa Sugita and Hiroshi Isshiki and Tadamitsu Kishimoto},
  journal={Blood},
  year={1992},
  volume={79 2},
  pages={460-6}
}
NF-IL6 was originally identified as a DNA binding protein regulating interleukin-1 (IL-1)-stimulated IL-6 expression. Direct cloning of NF-IL6 showed its homology with C/EBP, a hepatocyte- and adipocyte-specific transcription factor. This study showed that the expression of NF-IL6 messenger RNA (mRNA) increased markedly during the differentiation to a (mRNA) increased markedly during the differentiation to a macrophage lineage in mouse myeloid leukemia cells M1, human histiocytic leukemia cells… CONTINUE READING

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Macrophage differentiation - specific expression of NF - IL6 , a transcription factor for interleukin-6 .
TRANSCRIPTION FACTORIs biochemical function of gene productNF-kappa B
Macrophage differentiation - specific expression of NF - IL6 , a transcription factor for interleukin-6 .
Macrophage differentiation - specific expression of NF - IL6 , a transcription factor for interleukin-6 .
Direct cloning of NF - IL6 showed its homology with C / EBP , a hepatocyte- and adipocyte - specific transcription factor .
These results suggest that NF - IL6 may possibly be involved as an important transcription factor in the process of activation and/or differentiation of macrophages .
Particularly in HL-60 cells that undergo granulocyte or macrophage differentiation depending on inducers , NF - IL6 mRNA was specifically upregulated during macrophage differentiation but not granulocyte differentiation .
Particularly in HL-60 cells that undergo granulocyte or macrophage differentiation depending on inducers , NF - IL6 mRNA was specifically upregulated during macrophage differentiation but not granulocyte differentiation .
Particularly in HL-60 cells that undergo granulocyte or macrophage differentiation depending on inducers , NF - IL6 mRNA was specifically upregulated during macrophage differentiation but not granulocyte differentiation .
Particularly in HL-60 cells that undergo granulocyte or macrophage differentiation depending on inducers , NF - IL6 mRNA was specifically upregulated during macrophage differentiation but not granulocyte differentiation .
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