Macrophage-derived tumor necrosis factor alpha, an early developmental signal for motoneuron death.

@article{Sedel2004MacrophagederivedTN,
  title={Macrophage-derived tumor necrosis factor alpha, an early developmental signal for motoneuron death.},
  author={Fr{\'e}d{\'e}ric Sedel and Catherine B{\'e}chade and Sheela Vyas and Antoine Triller},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2004},
  volume={24 9},
  pages={2236-46}
}
Mechanisms inducing neuronal death at defined times during embryogenesis remain enigmatic. We show in explants that a developmental switch occurs between embryonic day 12 (E12) and E13 in rats that is 72-48 hr before programmed cell death. Half the motoneurons isolated from peripheral tissues at E12 escape programmed cell death, whereas 90% of motoneurons isolated at E13 enter a death program. The surrounding somite commits E12 motoneurons to death. This effect requires macrophage cells, is… CONTINUE READING
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