Macrophage-derived matrix vesicles: an alternative novel mechanism for microcalcification in atherosclerotic plaques.

@article{New2013MacrophagederivedMV,
  title={Macrophage-derived matrix vesicles: an alternative novel mechanism for microcalcification in atherosclerotic plaques.},
  author={Sophie E. P. New and Claudia Goettsch and Masanori Aikawa and Julio F.M. Marchini and Manabu Shibasaki and Katsumi Yabusaki and P. Scott Libby and Catherine M Shanahan and Kevin J. Croce and Elena Aikawa},
  journal={Circulation research},
  year={2013},
  volume={113 1},
  pages={72-7}
}
RATIONALE We previously showed that early calcification of atherosclerotic plaques associates with macrophage accumulation. Chronic renal disease and mineral imbalance accelerate calcification and the subsequent release of matrix vesicles (MVs), precursors of microcalcification. OBJECTIVE We tested the hypothesis that macrophage-derived MVs contribute directly to microcalcification. METHODS AND RESULTS Macrophages associated with regions of calcified vesicular structures in human carotid… CONTINUE READING
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