Macrophage-derived interleukin-18 in experimental renal allograft rejection.


BACKGROUND Interleukin 18 (IL-18) is primarily a macrophage-derived, pro-inflammatory cytokine. As macrophages can act as effector cells in acute rejection, we examined the role of IL-18 in a rat model of acute renal allograft rejection. METHODS Life-sustaining orthotopic DA to Lewis allograft and Lewis-Lewis isograft kidney transplants were performed. In… (More)


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@article{Wyburn2005MacrophagederivedII, title={Macrophage-derived interleukin-18 in experimental renal allograft rejection.}, author={Kate R Wyburn and Huiling Wu and Jianlin Yin and M Isabel De Jos{\'e} and Josette Marie Eris and Steven James Chadban}, journal={Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association}, year={2005}, volume={20 4}, pages={699-706} }