Macrophage-derived chemokine induces human eosinophil chemotaxis in a CC chemokine receptor 3- and CC chemokine receptor 4-independent manner.

@article{Bochner1999MacrophagederivedCI,
  title={Macrophage-derived chemokine induces human eosinophil chemotaxis in a CC chemokine receptor 3- and CC chemokine receptor 4-independent manner.},
  author={Bruce S Bochner and Carol A Bickel and M. Lonise Taylor and Donald W Macglashan and Patrick W. Gray and Carol J. Raport and Ronald Godiska},
  journal={The Journal of allergy and clinical immunology},
  year={1999},
  volume={103 3 Pt 1},
  pages={527-32}
}
BACKGROUND Chemokines are believed to contribute to selective cell recruitment. Macrophage-derived chemokine (MDC) is a CC chemokine that causes chemotaxis of dendritic cells, monocytes, and activated natural killer cells. MDC binds to CC chemokine receptor 4 (CCR4) but not to CCR1, CCR2, CCR3, CCR5, CCR6, or CCR7. OBJECTIVE Our aim was to determine the in vitro activity of MDC on human eosinophils by using chemotaxis and calcium flux assays. METHODS Eosinophils were purified from… CONTINUE READING
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