Macrophage-derived TGF-β in renal fibrosis: not a macro-impact after all.

MACROPHAGES ARE A GROUP of fascinating immune cells that play a critical role in mediating kidney injury, repair, and fibrosis (9). The vast majority, if not all, of the macrophages originate from myeloid precursors in the bone marrow and are released into circulation as monocytes (10). They then infiltrate the kidney and display a unique spectrum of… CONTINUE READING