Macrophage depletion induced by clodronate-loaded erythrocytes.

  title={Macrophage depletion induced by clodronate-loaded erythrocytes.},
  author={Luigia Rossi and Sonja Serafini and Antonella Antonelli and Francesca Pierig{\'e} and A. Carnevali and Valeria Battistelli and Manuela Malatesta and Emanuela Balestra and Raffaele Cali{\`o} and Carlo-Federico Perno and Mauro Magnani},
  journal={Journal of drug targeting},
  volume={13 2},
Given the important role of macrophages in various disorders, the transient and organ specific suppression of their functions may benefit some patients. Until now, liposome-encapsulated bisphosphonate clodronate has been extensively proposed to this end. In this paper, we demonstrate that erythrocytes loaded with clodronate can also be effective in macrophage depletion. Here, clodronate was encapsulated in erythrocytes through hypotonic dialysis, isotonic resealing and reannealing to final… CONTINUE READING