Macrophage depletion in the murine olfactory epithelium leads to increased neuronal death and decreased neurogenesis.

@article{Borders2007MacrophageDI,
  title={Macrophage depletion in the murine olfactory epithelium leads to increased neuronal death and decreased neurogenesis.},
  author={Aaron S. Borders and Marilyn L. Getchell and Jordan T Etscheidt and Nico Van Rooijen and Donald A. Cohen and Thomas V. Getchell},
  journal={The Journal of comparative neurology},
  year={2007},
  volume={501 2},
  pages={206-18}
}
Apoptosis of olfactory sensory neurons (OSNs) induced by olfactory bulbectomy (OBX) leads to the activation of resident macrophages within the olfactory epithelium (OE). These macrophages phagocytose degenerating OSNs and secrete chemokines, which recruit additional macrophages into the OE, and cytokines/growth factors, which regulate basal cell proliferation and differentiation and maturation of OSNs. In this study we apply for the first time the use of liposome-encapsulated clodronate to… CONTINUE READING
16 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 16 extracted citations

Similar Papers

Loading similar papers…