Macrophage depletion alters vein graft intimal hyperplasia.

  title={Macrophage depletion alters vein graft intimal hyperplasia.},
  author={John R. Hoch and V K Stark and Nico van van Rooijen and Jimmy L Kim and Mary P Nutt and Thomas F S C Warner},
  volume={126 2},
BACKGROUND The principal cause of vein graft failure is intimal hyperplasia (IH); however, its etiology remains unclear. In a rat model of vein graft IH we have observed prolonged transmural macrophage infiltration, leading us to hypothesize that these cells regulate IH. To test this, we used liposome-encapsulated dichloromethylene bisphosphonate (L-Cl2MBP… CONTINUE READING